About this role

Summary

The Neuroscience Department within BioMedical Research at Novartis Pharma AG in Basel, Switzerland, is searching for a motivated and experienced Research or Senior Scientist. This individual will assume a hands-on role within the in vivo neuroinflammation team and contribute to several research projects focused on the development of new therapies for neurodegenerative disorders, potentially helping improve the lives of millions of patients worldwide suffering neurodegenerative illnesses and conditions.

The main focus will be on novel neuroimmune cell pathways to elucidate the mechanisms at the molecular, cellular and ex vivo/in vivo level. Joining our team you will independently but with close collaboration with the other members of the Neurosciences group plan, execute, document, analyze and interpret experiments.

About the Role

Your responsibilities will include:

Designing, conducting and protocolling independently in vivo studies with specific focus on neuroinflammatory pathways
Establishment of new in vivo models for neuroinflammatory/neurodegenerative diseases
Performing and interpreting ex vivo analyses with emphasis on histology, biochemistry, FACS and molecular biology
Development and execution of in vitro cellular assays for assessing inflammatory processes
Presenting data and putting it in a complex context
Supporting general laboratory duties

Your profile:

University degree (MSc) or equivalent qualification, preferably in neuroscience, immunology, cell biology. *Please note that PhD candidates will not be considered for this position*
Minimum 2-3 years relevant lab based work experience in an industrial or academic setting
Previous experience in neuroscience drug discovery area would be an advantage.
Strong expertise in in vivo rodent work e.g. different routes of dosing, surgery, stereotactic brain injections, behavior, perfusion. Relevant animal experiment course available (e.g. LTK1)
Experience in different histological methods, microscopy and image analyses
Experience in RNA/DNA technologies and biochemistry, e.g. qPCR technologies, Westernblot
Good knowledge of immunology and immunological methods such as flow cytometry, HTRF, ELISA
Good knowledge in cell culture work, e.g. primary cells, iPSCs
Used to evaluating large datasets, strong documentation capabilities and interest to use new informatics analysis tools
Eager to learn and combine new techniques and concepts, to present results within the lab, to use and apply literature data, to perform exploratory activities and to work independently and as a team member
Scientific curiosity, initiative, commitment, flexibility and good organization skills
Track record of successful collaborations, open communication with different stakeholders, strong team player and networker
Excellent oral and written English