Roche Postdoctoral Fellow (RPF) - Mechanistic understanding of inflammatory fibroblasts in IBD
Updated: 16 Sep 2022
Offered by:F. Hoffmann-La Roche AG
The positionThis is a unique and exciting opportunity to work in the Immunology group at Roche, in close collaboration with Investigative & Immuno Safety (I2S - Pharmaceutical Sciences) and the Institute for Translational Bioengineering (ITB). As a Postdoctoral Fellow, you will focus on an exploratory research project focused on mechanistic understanding of fibroblast role in IBD pathogenesis. You will validate inflammatory fibroblast in-silico formulated hypotheses in a human advanced in vitro model combined with single-cell multi-omics phenotyping.This position is sponsored by the Roche Postdoctoral Fellowship Program. The RPF Program has the ambition to build and maintain the scientific leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers and leading academic research groups from around the world. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary, preceded by priority patent applications.The duration of RPF project is initially set for two years, with the possibility of extension for a third year. You will be based in Basel (Roche Innovation Center Site). Your Impact
- Leverage on systems biology and immunology disease kledge, coupled with established human models and single-cell genomics to investigate IBD pathogenesis
- Innovate and optimize state of the art cellular model and analytical tools to directly impact drug discovery in IBD, applying complex in vitro models of the vasculature
- Collaborate within the Immunology group and the broader pRED scientific community to improve our mechanistic kledge of inflammatory bowel disease (IBD) with the overall goal to bring new targets and advance them to clinics
- Optimize and apply cutting-edge in vitro immune-competent vascular models collaborating with the Vascular Group within Investigative & Immuno Safety.
- single-cell-omics and genetic manipulation (CRISPR KO), together with advanced in vitro models, to understand human disease
- Perform single cell RNA sequencing studies and analyze sequencing data
- Collaborate with the Organoid Development team at the Institute for Translational Bioengineering, applying single-cell genomic, imaging technologies and advanced computational tools to study complex biological systems such as immune-mesenchymal vascular interaction.
- Be part of a matrix research environment and embedded in a highly experienced researchers team with diverse backgrounds ranging from biology, immunology and bioengineering
- Generate high quality results for peer-reviewed publications and present at internal and external scientific meetings
- Liaise with other Immunology, PS, ITB and pRED colleagues to find synergies and possibilities to collaborate
- You are someone who wants to influence your own development. You are looking for a company where you have the opportunity to pursue your interests across functions and geographies. Working in a multicultural environment motivates you and, as a fast learner, you actively drive the quality of the requirements.
- You possess a PhD degree in Life Sciences (cellular/ molecular biology, pharmacology, immunology, bioengineering), or a closely related discipline. You have recently graduated and been actively engaged in scientific research continuously since his/her PhD (MD or MD/PhD) and ready to start an RPF postdoctoral activity no later than 5 years after PhD (MD or MD/PhD)
- You have strong technical and theoretical background/expertise in inflammatory disorders and advanced in vitro models and a good data science foundational kledge in the area of single cell genomics, with a proven track record in good experimental design.
- You are fluent in English and able to interact effectively with people with diverse expertise including biology, bioengineering and computer science.
- You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to design, perform, and interpret experiments, and to embark on new scientific methodologies.
When does it start?
The start date of this fellowship is October 2022, or on availability. Please clearly indicate your preferred starting date on your motivation letter.
All applications always need to include a CV, motivation letter and publication list.Do you k what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. For more information on the RPF Program, please visit: https://careers.roche.com/global/en/the-roche-postdoctoral-fellowship-programme Roche is an equal opportunity employer.
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche. Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.